Laboratory of Modification of Biologically Active Compounds

Head Anatoliy I. Potopalsky, PhD (med.sci.) Phone: (380-44) 526-11-39; Fax: (380-44) 526-07-59; E-mail: potopalsky@imbg.org.ua WEB: www.potopalsky.kiev.ua

Scientific directions:

The development of methods for modification of biologically active substances and the study on the molecular aspects of their actions.

Current scientific research:

The mechanisms of alkylation of amines, nucleic acids and their components by the ethyleneimine derivatives are studied. The products of alkylation were purified and characterized, their biological activity being studied in different systems, and antitumoral, antiviral, and immunomodulating effects were found.

Novel medications were obtained and the ways of their application in medicine, veterinary, and agri­culture for the influence on biological processes have been developed. The preparation Izatizon which has a wide range of antiviral, antitumoral and antibacterial effects, was registered in veterinary for treatment and prevention of viral diseases of birds and agricultural livestock, it was also recommend­ed to cure people with viral diseases and tumors. New medicinal Izatizon forms (e.g. Izatizoniy) are being developed and tested.

The preparations of stimulators of plants growth are being developed on the basis of nucleic acids and their components. The methods of using native and modified nucleic acids to change the genetic appa­ratus are being developed. The genetic effects of alkyl DNAs were determined and new forms of rye, mil­let, and tomatoes with valuable features were obtained. Special kind of feed lupine with high protein content Industrialnuy (i.e. industrial) and a kind of pumpkin Kavbuz Zdorovjaga (i.e. watermelon/pumpkin, giant) were registered at State sorts register of Ukraine.

Experimental study on modificated products of alkaloids, their analogues and derivaties with wide range of activity is being conducted. The results of these researches are used for improvement of human health and environment.

Prof. A.I. Potopalsky together with former colleagues V.Novytsky (Austria) and M.Oliyovska were nom­inated to Nobel Prize in medical chemistry in 2004 for the development of antitumoral medications based on celandine alkaloids modification. Amitozyn, antitumoral medication of this kind, passed State clinical testing on the patients with malignant tumors of 3 and 4 degrees and was recommended for the application in medicine.

A.I. Potopalsky is the Honored inventor of Ukraine.

Selected publications:

1. Potopalsky A. I., Celadine Preparations in Biology and Medicine, Kyiv, Naukova Dumka, -1992. -200P.
2. Potopalsky A. I., Lozyuk L.V., Antiviral, antitumoral medicine IZATIZON. -Lviv, Naukova Dumka -1995. -P.90.
3. Potopalsky A. I., Yurkevych L.N., May the Third millennium have new plants for health, welfare, beauty, and longevity. - Kyiv, Kolobig - 2005. - P. 168.
4. Potopalsky A. I. The development of phytochemical antitumoral medicine of amitozyn with antiviral and immunomodulating effect is the beginning of new scientific direction of molecular sanitation of humans and the environment/ /Materials of international scientific and practical forum The Basis of molecular and genetic sanitation of humans and the environment. - Kyiv, - May 31- June 1, 2005 -P. 163-166.