Department of Biomolecular Electronics
Alexey P. Soldatkin
Member of National Academy of Sciences of Ukraine,
Dr. Sci. (biotechnology), Professor
Phone: (380-44) 200-03-28;
Fax: (380-44) 526-07-59;
Scientific activity:The Department of Biomolecular Electronics is focused on the development of electrochemical (amperometric, potentiometric (ISFET), conductometric) and optical chemo/biosensors for monitoring of environmental and food contamination, quality control of food and pharmaceutical products, control of biotechnological processes and for medical diagnosis. Our scientific team has a strong experience in bio/chemo sensor development, in immobilization of DNA, enzymes, antibodies, proteins, calixarenes and whole cells onto microelectrodes based on carbon, gold, platinum and others materials. To improve analytical parameters of biosensors (sensitivity, limit of detection, linear range, selectivity etc.) different approaches are applied by our team, i.e. use of innovative electrode materials with improved design; modification of electrodes and bioselective layer by polymers (PPD, PVA-SbQ, etc.) and nanomaterials (carbon nanotubes, nanodiamonds, zeolites, gold nanoparticles, etc.).
- Development of micro/nano electrochemical bio- and chemo-sensors for the determination of some neurotransmitters (acetylcholine, glutamate, etc.), alcohols, carbohydrates, aldehydes, toxic substances (heavy metal ions, pesticides, aflatoxins, etc.), urea, ammonium, arginine and blood metabolites in vitro and in vivo.
- Application of nanomaterials (carbon nanotubes, gold nanoparticles, nanodiamonds and zeolites) to improve analytical characteristics of bio- and chemo-sensors.
- Application of new genetically engineered proteins and synthetic molecules as a recognition element for sensors with improved analytical characteristics.
- Creation and study of synthetic analogues of biological receptors by molecular imprinting (molecular imprinted polymers - MIP) and their implementation in sensor technology, solid phase extraction and chromatography.
- Development of electrochemical and optical affine (immune- and DNA-) sensors.
- Study on fundamentals of the interaction of immobilized enzymes with substrates and inhibitors using electrochemical sensors.