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.: (380-44) 526-20-16;
: (380-44) 526-07-59;
E-mail: ztkachuk@yahoo.com
ztkachuk@bigmir.net

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19651970 , , , , ()

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1974 ( )

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19911992

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  • 2018-2019 - - ̳ 26 2018 . 543-

쳿 :

  • 2015-2019 " " ֳ " 㳿 , ", 35
  • 20132014 Fundamentals of the development of anticancer and antiviral drugs ( .., ..)
  • 20092013 To study the mechanism of 2, 5-oligoadenylate interaction with calcium-binding proteins ( ..)
  • 20072010 To study the mechanism of calmodulin activation of core 2-5-oligoadenylates and their analogues and the synthesis and study of biological activity of new ligands based on oligonucleotides ( ..)
  • 20042008 To study the interaction of 2-5-oligoadenylate analogues with fosfodiesterase of cyclic nucleotides and to monitor new anti-inflammatory drugs in vitro and in vivo ( .., ..).

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  • 2016-2017 " 䳿 "

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  • 쳿 , (, )
  • International Institute of Molecular and Cell Biology, (, )
  • Université de Strasbourg (, )

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  1. Marchyshak T.V., Yakovenko T.G., Tkachuk Z.Yu. Influence of oligoribonucleotides-D-mannitol complexes on the expression of genes under acute thioacetaamide-induced hepatotoxicity. Reports of the National Academy of Sciences of Ukraine, N 7, 2018. . 96-102
  2. Skorobogatov OY, Kukharenko AP, Kozlov OV, Dubey IY and Tkachuk ZY. 2'-5'-Linked Triadenylates Act as Protein Kinase Activity Modulators. Journal of Proteomics & Bioinformatics. 2018. V. 10, 12. . 320-323. DOI: 10.4172/jpb.1000457
  3. Marchyshak T.V., Yakovenko T.G., Igor Shmarakov, Tkachuk Z.Yu. The Potential Protective Effect of Oligoribonucleotides-d-Mannitol Complexes against Thioacetamide-Induced Hepatotoxicity in Mice. Pharmaceuticals, N 11 (3), 2018. .1-14. doi:https://doi.org/10.3390/ph11030077
  4. Melnichuk N., Semernikova L., Tkachuk Z. Complexes of Oligoribonucleotides with D-Mannitol Inhibit HemagglutininGlycan Interaction and Suppress Influenza A Virus H1N1 (A/FM/1/47) Infectivity In Vitro. Pharmaceuticals. 2017. V. 10, 3: 71. DOI: 10.3390/ph10030071
  5. Melnichuk N., Semernikova L., Tkachuk Z.. Study on oligoribonucleotides-D-mannitol complexes effects on the influenza A virus H1N1 (A/FM/1/47) infectivity in vitro and expression of some host genes under the influenza infection in vivo. Biopolymers and Cell. 2017. Vol. 33. N 3: 229
  6. K. Ferenc,T. Pilżys, T. Skrzypek, D. Garbicz, M. Marcinkowski, M. Dylewska,P. Gładysz, O. Skorobogatov, Z. Gajewski, E. Grzesiuk, R. Zabielski. Structure and Function of Enterocyte in Intrauterine Growth Retarded Pig Neonates. Hindawi Disease Markers. Article ID 5238134 (9 pages), 2017. doi:10.1155/2017/5238134
  7. .. ³, .. , .. , .. . , . . , 2016, 10: 78-83.
  8. Melnichuk N., Vivcharyk M., Tkachuk Z. Effect of Oligoribonucleotides-D-mannitol complex on the hemagglutinin of influenza A (H1N1) virus. 8th International conference bioresources and viruses, 12-14th September 2016, Kyiv, Ukraine. 2016. Abstract P. 45-46.
  9. Shmarakov IO, Marchyshak TV, Borschovetska VL, Marchenko MM, Tkachuk ZYu. Hepatoprotective activity of exogenous RNA. Ukr. Biochem. J. 2015; 87(4):37-44.
  10. Chernega OI, Levchenko SM. Nature of the lowest electronic transition of thia- and quino-cianines with fluori-nated polimethine chaine. Dyes and Pigments. 2015; 123:176-185.
  11. , *, , , β, . ﳿ -. . 2015;21(2):252-257.
  12. ., ., ., . - Nicolet iS50 . . 2014;6(47):110-113.
  13. Tkachuk Z. Multiantivirus compo-und, composition and method for treatment of virus disease. US patent. 2014;#8,722,642 B2:61.
  14. Tkachuk ZYu, Kozlov AV, Skorobogatov OYu. Structural Changes In Therapeutic RNAs. Macromolecular Symposia. 2014;335:17-19.
  15. Levchenko SM, Rebriev AV, Tkachuk VV, et al. The detection of interaction betwe-en oligonucleotides and interferon, a key protein of antiviral cell defense system. Mol.Cryst.Liq.Cryst. 2014;590(1):213-220.
  16. Viniychuk OO, Levchenko SM, Przhonska OV, et al. Electronic transition in polymerthine dyes involving local and delocalized levels. Jour.Mol.Str. 2014;1060:30-37.
  17. Bashmakova N, Shaydyuk E, Levchenko S, et al. Desigh and electronic structure of new styryl dye bases: steady-state and time resolved spectrosco-pic studies. Journal of Physical Chemistry A. 2014;118(25):4502-4509.
  18. Skorobogatov O, Lozhko D, Zhukov I, et al. Impact of dephos-phorylated 2'-5'-linked oligoade-nylates on apo-S100A1 proteins conformation, studied by hetero-nuclear NMR and circular dichroism. Biopolym. Cell. 2014;30:279-285.
  19. Tkachuk ZYu. 2'5'Oligoadenylates as a "tool" of innate immunity. Biopolym. Cell. 2013; 29(4):26676. doi:10.7124/bc.000821
  20. Levchenko SM, Rebriev AV, Tkachuk VV, Dubey LV, Dubey IYa, Tkachuk ZYu. Studies on the interaction of oligoadenylates with proteins by MALDITOF mass spectrometry. Biopolym. Cell. 2013; 29(1):428. doi: 10.7124/bc.000804
  21. Tkachuk Z. Multiantivirus compound, composition and method for treatment of virus disease. United States Patent 2013 N 8,420,617 B2. Apr.16, P. 38.
  22. Tkachuk ZYu, Sotska YaA, Frolov VM, Kruglova OA. Nuclex therapy for patients with chronic hepatitis C. Int. J. Immunological Studies. 2012; 1(4):34964. doi:10.1504/IJIS.2012.051236
  23. Frolov VM, Tkachuk ZYu, Kruglova OA. Application of immuno modulator Nucleinat in clinical practice Infections Diseases. 2012. 4:8290.
  24. Tkachuk ZYu, Dubey L, Tkachuk VV, et al. Studying the interaction of 2'5'oligoadenylate and their counterparts from proteins by fluorescence spectroscopy. Ukr.biohim.Zh. 2011; 83(1):4553.
  25. Tkachuk Z. Compound, compozision and method for treatment of inflammatory and inflammatoryrelated disorders. United States Patent2004 N US 6,737,271. May 18, P.38.